THE COLLABORATION BEGINS
Dr. Jean Bennett & Dr. Katherine High meet and collaborate at several gene therapy seminars and retreats.
THE PATH TO GENE THERAPY
Dr. Bennett begins working at the University of Pennsylvania with her husband, Dr. Albert Maguire, to explore gene therapy as a treatment for vision loss.
AMAZING DATA IN DOGS
Dr. Bennett and team successfully restore sight to dogs with a canine form of Leber’s congenital amaurosis (LCA).
MEETING OF THE MINDS
Dr. High meets with Dr. Steven Altschuler, securing funding through the Children’s Hospital of Philadelphia (CHOP) for a human clinical trial to test Dr. Bennett’s discoveries.
Dr. Bennett & Dr. High pair up to begin the first human clinical gene therapy trials in LCA patients, yielding extraordinary results.
IN GOOD COMPANY
Spark Therapeutics is founded by CHOP with Dr. High as President to develop this treatment into a drug – Luxturna™.
A VISION REALIZED
Luxturna™ becomes the first gene therapy drug to earn FDA approval.
AN INAUGURAL HONOR
Dr. Bennett & Dr. High win the Sanford Lorraine Cross Award for their groundbreaking innovation and problem solving.